ea0016p495 | Obesity | ECE2008
Bollheimer Cornelius
, Harle Peter
, Schaffler Andreas
, Buchler Christa
, Wrede Christian
, Straub Rainer
, Scholmerich Jurgen
, Buttner Roland
Background: Obese patients show an increased activity of the sympathetic nervous system, but the causality of the relationship is not known. Here, we examine whether a pharmacologic sympathectomy influences diet-induced obesity and insulin resistance in the high fat fed rat model.Methods: Wistar-Rats were fed ad libitum with a high fat diet (HF, 40 energy% of fat, based on lard) for 12 weeks. A pharmacologic sympathectomy was performed by a) weekl...